The Ephrata Cloister is located at 632 West Main Street in Ephrata, Pennsylvania.

From the Pennsylvania Turnpike: take exit 286 (old exit 21) to Route 222 South. Exit at the Ephrata exit on to Route 322 West. Turn right off the exit and travel on 322 West (Main Street) for 2.5 miles. The entrance to the Ephrata Cloister is on the left side of the street.

From Lancaster: take Route 222 North to the Ephrata exit, Route 322 west. Turn left off the exit and travel on 322 West (Main Street) for 2.5 miles. The entrance to the Ephrata Cloister is on the left side of the street.